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Conolidine’s analgesic effects stem from its conversation with non-opioid pain pathways. Compared with opioids, which bind to µ-opioid receptors in the central anxious process, conolidine modulates alternate molecular targets. A Science Advancements analyze found that conolidine interacts Together with the atypical chemokine receptor ACKR3/CXCR7
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